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Article

EGFR gene alterations as a prognostic biomarker in advanced esophageal squamous cell carcinoma.

Frontiers in bioscience (Landmark edition) - 1 Jan 2010

Kaneko Kazuhiro, Kumekawa Yosuke, Makino Reiko, Nozawa Hisako, Hirayama Yuichi, Kogo Mari, Konishi Kazuo, Katagiri Atsushi, Kubota Yutaro, Muramoto Takashi, Kushima Miki, Ohmori Tohru, Oyama Tsunehiro, Kagawa Norio, Ohtsu Atsushi, Imawari Michio

Abstract excerpt

Esophageal squamous cell carcinoma (ESCC) exhibits abnormalities in epidermal growth factor receptor (EGFR) gene. To identify a prognostic marker, the overexpression of EGFR protein, mutations in EGFR and p53 mutations were analyzed in pretreatment biopsy specimens removed from T3-4 and/or M1 LYM ESCC patients who received chemoradiotherapy. A silent mutation comprised of a single nucleotide polymorphism (SNP) at...

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Identifiers

PMID: 20036807
DOI: 10.2741/3607

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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