Article
EGFR R497K polymorphism is a favorable prognostic factor for advanced lung cancer.
Journal of cancer research and clinical oncology - 1 Feb 2009
Sasaki Hidefumi, Okuda Katsuhiro, Shimizu Shigeki, Takada Minoru, Kawahara Masaaki, Kitahara Naoto, Okumura Meinoshin, Matsumura Akihide, Iuchi Keiji, Kawaguchi Tomoya, Kubo Akihito, Kawano Osamu, Yukiue Haruhiro, Yano Motoki, Fujii Yoshitaka
Abstract excerpt
INTRODUCTION: It has been reported that the R497K polymorphism of the epidermal growth factor receptor (EGFR) gene has attenuated functions in ligand binding, tyrosine kinase activation, and growth stimulation. On other hand, EGFR gene mutations at kinase domain in non-small cell lung cancer (NSCLC) have been examined for their ability to predict sensitivity to gefitinib or erlotinib. MATERIALS AND METHODS: We...
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