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Article

CYP1B1 and endothelial nitric oxide synthase combine to sustain proangiogenic functions of endothelial cells under hyperoxic stress.

American journal of physiology. Cell physiology - 1 Mar 2010

Tang Yixin, Scheef Elizabeth A, Gurel Zafer, Sorenson Christine M, Jefcoate Colin R, Sheibani Nader

Abstract excerpt

We have recently shown that deletion of constitutively expressed CYP1B1 is associated with attenuation of retinal endothelial cell (EC) capillary morphogenesis (CM) in vitro and angiogenesis in vivo. This was largely caused by increased intracellular oxidative stress and increased production of t...

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Identifiers

PMID: 20032512
DOI: 10.1152/ajpcell.00153.2009
PMCID: PMC2838582

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20032512-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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