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Article

Biliverdin reductase deficiency triggers an endothelial-to-mesenchymal transition in human endothelial cells.

Archives of biochemistry and biophysics - 15 Dec 2019

Klóska Damian, Kopacz Aleksandra, Piechota-Polańczyk Aleksandra, Neumayer Christoph, Huk Ihor, Dulak Józef, Józkowicz Alicja, Grochot-Przęczek Anna

Abstract excerpt

Endothelial dysfunction accompanied by the loss of endothelial cell phenotype plays an essential role in cardiovascular diseases. Here, we report that knockdown of biliverdin reductase (BVR), the enzyme of the heme degradation pathway converting biliverdin to bilirubin, shifts endothelial phenotype of the primary human aortic endothelial cells (HAECs) to mesenchymal-like one. It is reflected by the loss of...

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PMID: 31704097
DOI: 10.1016/j.abb.2019.108182

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