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Article

PEDF expression affects retinal endothelial cell proangiogenic properties through alterations in cell adhesive mechanisms.

American journal of physiology. Cell physiology - 1 Oct 2017

Falero-Perez Juliana, Park SunYoung, Sorenson Christine M, Sheibani Nader

Abstract excerpt

Pigment epithelium-derived factor (PEDF) is an endogenous inhibitor of angiogenesis. Although various ocular cell types including retinal endothelial cells (EC) produce PEDF, we know very little about cell autonomous effects of PEDF in these cell types. Here we determined how PEDF expression affects retinal EC proangiogenic properties. Retinal EC were prepared from wild-type (PEDF+/+) and PEDF-deficient (PEDF-/-)...

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Identifiers

PMID: 28747334
DOI: 10.1152/ajpcell.00004.2017
PMCID: PMC5668572

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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