Article
Single nucleotide polymorphisms at the ADIPOQ gene locus interact with age and dietary intake of fat to determine serum adiponectin in subjects at risk of the metabolic syndrome.
The American journal of clinical nutrition - 1 Jul 2011
AlSaleh Aseel, O'Dell Sandra D, Frost Gary S, Griffin Bruce A, Lovegrove Julie A, Jebb Susan A, Sanders Thomas A B
Abstract excerpt
BACKGROUND: Adiponectin gene expression is modulated by peroxisome proliferator-activated receptor γ, which is a transcription factor activated by unsaturated fatty acids. OBJECTIVE: We investigated the effect of the interaction between variants at the ADIPOQ gene locus, age, sex, body mass index (BMI), ethnicity, and the replacement of dietary saturated fatty acids (SFAs) with monounsaturated fatty acids (MUFAs)...
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