Article
Association and functional analyses of MEF2A as a susceptibility gene for premature myocardial infarction and coronary artery disease.
Circulation. Cardiovascular genetics - 1 Apr 2009
Guella Ilaria, Rimoldi Valeria, Asselta Rosanna, Ardissino Diego, Francolini Maura, Martinelli Nicola, Girelli Domenico, Peyvandi Flora, Tubaro Marco, Merlini Pier Angelica, Mannucci Pier Mannuccio, Duga Stefano
Abstract excerpt
BACKGROUND: Mutations in the MEF2A gene, coding for a member of the myocyte enhancer factor 2 family of transcription factors, have been reported in patients with coronary artery disease and myocardial infarction (MI). In particular, a 21-bp deletion and 3 missense mutations were demonstrated either to reduce MEF2A transcriptional activity or to impair its nuclear translocation. However, the association of MEF2A...
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