Article
Transcription factor MEF2A mutations in patients with coronary artery disease.
Human molecular genetics - 15 Dec 2004
Bhagavatula M R Krishna, Fan Chun, Shen Gong-Qing, Cassano June, Plow Edward F, Topol Eric J, Wang Qing
Abstract excerpt
Coronary artery disease (CAD), including its most serious complication myocardial infraction (MI), is the leading cause of death in the US and developed countries. We recently discovered that a seven-amino acid deletion in MEF2A, a transcription factor with a high level of expression in the endothelium of coronary arteries, co-segregates with CAD/MI in one family, and it suppresses transcription activation...
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