Article
A study of the role of the Myocyte-specific Enhancer Factor-2A gene in coronary artery disease.
Atherosclerosis - 1 Mar 2010
Elhawari Samar, Al-Boudari Olyan, Muiya Paul, Khalak Hanif, Andres Editha, Al-Shahid Maie, Al-Dosari Mohammed, Meyer Brian F, Al-Mohanna Futwan, Dzimiri Nduna
Abstract excerpt
We evaluated the role of the MEF2A as a risk factor for coronary artery disease (CAD) in 1186 subjects with angiographically documented disease compared with 885 CAD-free individuals in the Saudi population. Screening the gene revealed exon 11 as the most polymorphic of all coding regions, harbouring several substitution polymorphisms and insertion/deletions (indels) at a locus containing an 11 CAG trinucleotide...
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