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Article

Bioluminescent nanosensors for protease detection based upon gold nanoparticle-luciferase conjugates.

Chemical communications (Cambridge, England) - 7 Jan 2010

Kim Young-Pil, Daniel Weston L, Xia Zuyong, Xie Hexin, Mirkin Chad A, Rao Jianghong

Abstract excerpt

This communication reports the use of click chemistry to site-specifically conjugate bioluminescent Renilla luciferase proteins to gold nanoparticles (Au NPs) for sensing protease activity. The bioluminescent emission from luciferase was efficiently quenched by Au NPs, but significantly recovered after the proteolytic cleavage.

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Identifiers

PMID: 20024298
DOI: 10.1039/b915612g
PMCID: PMC3930333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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