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Article

Her4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro system.

The Journal of biological chemistry - 5 Mar 2010

Monsey John, Shen Wei, Schlesinger Paul, Bose Ron

Abstract excerpt

Her4 (ErbB-4) and Her2/neu (ErbB-2) are receptor-tyrosine kinases belonging to the epidermal growth factor receptor (EGFR) family. Crystal structures of EGFR and Her4 kinase domains demonstrate kinase dimerization and activation through an allosteric mechanism. The kinase domains form an asymmetric dimer, where the C-lobe surface of one monomer contacts the N-lobe of the other monomer. EGFR kinase dimerization...

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Identifiers

PMID: 20022944
DOI: 10.1074/jbc.M109.096032
PMCID: PMC2844153

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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