Article
Mapping C-terminal transactivation domains of the nuclear HER family receptor tyrosine kinase HER3.
PloS one - 1 Jan 2013
Brand Toni M, Iida Mari, Luthar Neha, Wleklinski Matthew J, Starr Megan M, Wheeler Deric L
Abstract excerpt
Nuclear localized HER family receptor tyrosine kinases (RTKs) have been observed in primary tumor specimens and cancer cell lines for nearly two decades. Inside the nucleus, HER family members (EGFR, HER2, and HER3) have been shown to function as co-transcriptional activators for various cancer-promoting genes. However, the regions of each receptor that confer transcriptional potential remain poorly defined. The...
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