Article
Interleukin-4 promotes the expansion of skin-infiltrating lymphocytes from atopic dermatitis in vitro.
The Journal of investigative dermatology - 1 Mar 1991
Reinhold U, Kukel S, Goeden B, Neumann U, Wehrmann W, Kreysel H W
Abstract excerpt
Functional studies of lymphocytes in atopic dermatitis (AD) have so far focused on peripheral blood mononuclear cells (PBMC), whereas cells at the involved site, the skin, have not been examined. Accordingly, we have developed methods to generate lymphocyte cultures from biopsies of inflammatory skin areas. Skin-infiltrating lymphocytes (SIL) were isolated from skin biopsies of 6 patients with severe AD and...
Topics
- Adult
- Biopsy
- Cells, Cultured
- Dermatitis, Atopic
- Female
- Humans
- Interleukin-4
- Leukocytes, Mononuclear
- Lymphocytes
- Male
- Phenotype
- Skin