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Article

Mutation in lamin A/C sensitizes the myocardium to exercise-induced mechanical stress but has no effect on skeletal muscles in mouse.

Neuromuscular disorders : NMD - 1 Aug 2016

Cattin Marie-Elodie, Ferry Arnaud, Vignaud Alban, Mougenot Nathalie, Jacquet Adeline, Wahbi Karim, Bertrand Anne T, Bonne Gisèle

Abstract excerpt

LMNA gene encodes lamin A/C, ubiquitous proteins of the nuclear envelope. They play crucial role in maintaining nuclear shape and stiffness. When mutated, they essentially lead to dilated cardiomyopathy with conduction defects, associated or not with muscular diseases. Excessive mechanical stress sensitivity has been involved in the pathophysiology. We have previously reported the phenotype of Lmna(delK32) mice,...

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Source

Identifiers

PMID: 27287550
DOI: 10.1016/j.nmd.2016.05.010

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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