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Article

MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein.

The Journal of biological chemistry - 19 Oct 2001

Masuda K, Shima H, Watanabe M, Kikuchi K

Abstract excerpt

Mitogen-activated protein kinase (MAPK) phosphatases (MKPs) negatively regulate MAPK activity. In the present study, we have identified a novel MKP, designated MKP-7, and mapped it to human chromosome 12p12. MKP-7 possesses a long C-terminal stretch containing both a nuclear export signal and a nuclear localization signal, in addition to the rhodanese-like domain and the dual specificity phosphatase catalytic...

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Identifiers

PMID: 11489891
DOI: 10.1074/jbc.M104600200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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