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Article

CLOCK may predict the response to fluvoxamine treatment in Japanese major depressive disorder patients.

Neuromolecular medicine - 1 Jan 2009

Kishi Taro, Kitajima Tsuyoshi, Ikeda Masashi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Okochi Tomo, Okumura Takenori, Tsunoka Tomoko, Ozaki Norio, Iwata Nakao

Abstract excerpt

Recent studies have shown that selective serotonin reuptake inhibitors (SSRIs) have circadian properties, suggesting that the antidepressive action of SSRIs may also be attributable to circadian mechanisms. Another study reported an association between clock gene (CLOCK) and improvements in insomnia symptoms from SSRIs treatment. Therefore, we examined the association between CLOCK and the efficacy of fluvoxamine...

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Source

Identifiers

PMID: 19347611
DOI: 10.1007/s12017-009-8060-7

Genes

CLOCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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