Article
Rescue of motor coordination by Purkinje cell-targeted restoration of Kv3.3 channels in Kcnc3-null mice requires Kcnc1.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 Dec 2009
Hurlock Edward C, Bose Mitali, Pierce Ganon, Joho Rolf H
Abstract excerpt
The role of cerebellar Kv3.1 and Kv3.3 channels in motor coordination was examined with an emphasis on the deep cerebellar nuclei (DCN). Kv3 channel subunits encoded by Kcnc genes are distinguished by rapid activation and deactivation kinetics that support high-frequency, narrow action potential firing. Previously we reported that increased lateral deviation while ambulating and slips while traversing a narrow...
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