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Article

The puzzling role of TRPC3 channels in motor coordination.

Pflugers Archiv : European journal of physiology - 1 Feb 2010

Trebak Mohamed

Abstract excerpt

Transient receptor potential canonical 3 (TRPC3) proteins are nonselective cation channels activated downstream of phospholipase-C-coupled receptors. TRPC3 channels have emerged as major players in the function of the central nervous system. They have been described as important contributors to brain-derived neurotrophic factor mediated survival and growth-cone guidance of cerebellar granule neurons. TRPC3 were...

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Source

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Identifiers

PMID: 19823866
DOI: 10.1007/s00424-009-0740-5
PMCID: PMC3164554

Genes

TRPC3

Provenance

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Related research

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The puzzling role of TRPC3 channels in motor coordination.PMID 19823866Read ↗

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Phenotypical, genotypical and pathological characterization of the moonwalker mouse, a model of ataxia.Semantic proximity Read ↗

Functional and structural basis of a hypermorphic TRPC3 variant.Semantic proximity Read ↗

Candidate screening of the TRPC3 gene in cerebellar ataxia.Semantic proximity Read ↗

Purkinje-cell-restricted restoration of Kv3.3 function restores complex spikes and rescues motor coordination in Kcnc3 mutants.Semantic proximity Read ↗

Case Report: Expanded delineation of phenotype of TRPM3-related neurodevelopmental disordersSemantic proximity Read ↗

Rescue of motor coordination by Purkinje cell-targeted restoration of Kv3.3 channels in Kcnc3-null mice requires Kcnc1.Semantic proximity Read ↗

The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice.Semantic proximity Read ↗

KCC3 deficiency-induced disruption of paranodal loops and impairment of axonal excitability in the peripheral nervous system.Semantic proximity Read ↗

Modeling Suggests TRPC3 Hydrogen Bonding and Not Phosphorylation Contributes to the Ataxia Phenotype of the Moonwalker Mouse.Semantic proximity Read ↗

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TRPC3: a multifunctional signaling molecule.Semantic proximity Read ↗

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