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Article

Arcuate nucleus proopiomelanocortin neurons mediate the acute anorectic actions of leukemia inhibitory factor via gp130.

Endocrinology - 1 Feb 2010

Grossberg Aaron J, Scarlett Jarrad M, Zhu XinXia, Bowe Darren D, Batra Ayesha K, Braun Theodore P, Marks Daniel L

Abstract excerpt

The proinflammatory cytokine leukemia inhibitory factor (LIF) is induced in disease states and is known to inhibit food intake when administered centrally. However, the neural pathways underlying this effect are not well understood. We demonstrate that LIF acutely inhibits food intake by directly activating pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus. We show that arcuate POMC...

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Source

Open in PubMed Open full text

Identifiers

PMID: 20016025
DOI: 10.1210/en.2009-1135
PMCID: PMC2817620

Genes

LIF
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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