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Article

Inhibition of hypothalamic leukemia inhibitory factor exacerbates diet-induced obesity phenotype.

Journal of neuroinflammation - 2 Sept 2017

Fioravante Milena, Bombassaro Bruna, Ramalho Albina F, Dragano Nathalia R, Morari Joseane, Solon Carina, Tobar Natalia, Ramos Celso D, Velloso Licio A

Abstract excerpt

BACKGROUND: The consumption of large amounts of dietary fats can trigger an inflammatory response in the hypothalamus and contribute to the dysfunctional control of caloric intake and energy expenditure commonly present in obesity. The objective of this study was to identify chemokine-related transcripts that could be involved in the early stages of diet-induced hypothalamic inflammation. METHODS: We used...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28865476
DOI: 10.1186/s12974-017-0956-9
PMCID: PMC5581454

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