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Article

Leukemia inhibitory factor signaling is implicated in embrionic development of the HPA axis.

FEBS letters - 15 Aug 2005

Ware Carol B, Kariagina Anastasia, Zonis Svetlana, Alon Dana, Chesnokova Vera

Abstract excerpt

Leukemia inhibitory factor (LIF) is expressed in the hypothalamic-pituitary adrenal (HPA) axis and stimulates pituitary POMC transcription. The role of LIF receptor signaling in HPA axis development was examined. Lifr -/- and Lifr +/+ fetuses were obtained by Cesarean section on E18.5. Despite a 3-fold induction of hypothalamic CRH mRNA, pituitary POMC mRNA and RU486-induced ACTH levels were decreased in Lifr -/-...

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Share to Pituitary Gland, Anterior

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Source

Identifiers

PMID: 16081071
DOI: 10.1016/j.febslet.2005.07.014

Genes

LIF
CRH
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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