Article
Resistance-associated mutations to etravirine (TMC-125) in antiretroviral-naïve patients infected with non-B HIV-1 subtypes.
Antimicrobial agents and chemotherapy - 1 Feb 2010
Maïga Almoustapha Issiaka, Descamps Diane, Morand-Joubert Laurence, Malet Isabelle, Derache Anne, Cisse Mamadou, Koita Victoria, Akonde Alain, Diarra Bah, Wirden Marc, Tounkara Anatole, Verlinden Yvan, Katlama Christine, Costagliola Dominique, Masquelier Bernard, Calvez Vincent, Marcelin Anne-Genevieve
Abstract excerpt
Susceptibility to etravirine (ETR), an expanded-spectrum nonnucleoside reverse transcriptase inhibitor (NNRTI), is dependent on the type and number of NNRTI resistance-associated mutations (RAMs). Studies have shown that some HIV-1 subtypes may have natural polymorphisms described as ETR RAMs. Th...
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