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Article

Resistance profile of etravirine: combined analysis of baseline genotypic and phenotypic data from the randomized, controlled Phase III clinical studies.

AIDS (London, England) - 20 Feb 2010

Vingerhoets Johan, Tambuyzer Lotke, Azijn Hilde, Hoogstoel Annemie, Nijs Steven, Peeters Monika, de Béthune Marie-Pierre, De Smedt Goedele, Woodfall Brian, Picchio Gastón

Abstract excerpt

OBJECTIVE: To refine the genotypic and phenotypic correlates of response to the nonnucleoside reverse transcriptase inhibitor etravirine. DESIGN: Initial analyses identified 13 etravirine resistance-associated mutations (RAMs) and clinical cutoffs (CCOs) for etravirine. A multivariate analysis was performed to refine the initial etravirine RAM list and improve the predictive value of genotypic resistance testing...

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PMID: 20051805
DOI: 10.1097/QAD.0b013e32833677ac

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