Article
HIV-1 subtype B-infected MSM may have driven the spread of transmitted resistant strains in France in 2007-12: impact on susceptibility to first-line strategies.
The Journal of antimicrobial chemotherapy - 1 Jul 2015
Frange Pierre, Assoumou Lambert, Descamps Diane, Chéret Antoine, Goujard Cécile, Tran Laurent, Gousset Marine, Avettand-Fenoël Veronique, Bocket Laurence, Fafi-Kremer Samira, Guinard Jerome, Morand-Joubert Laurence, Nicot Florence, Plantier Jean-Christophe, Rogez Sylvie, Wirden Marc, Rouzioux Christine, Meyer Laurence, Chaix Marie-Laure
Abstract excerpt
BACKGROUND: Our study describes the prevalence of transmitted drug resistance (TDR) among 1318 French patients diagnosed at the time of primary HIV-1 infection (PHI) in 2007-12. METHODS: HIV-1 resistance-associated mutations (RAMs) were characterized using both the 2009 WHO list of mutations and the French ANRS algorithm. A genotypic susceptibility score was estimated for each first-line recommended ART...
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