Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.

Nature - 6 Feb 2014

Tumbale Percy, Williams Jessica S, Schellenberg Matthew J, Kunkel Thomas A, Williams R Scott

Abstract excerpt

Faithful maintenance and propagation of eukaryotic genomes is ensured by three-step DNA ligation reactions used by ATP-dependent DNA ligases. Paradoxically, when DNA ligases encounter nicked DNA structures with abnormal DNA termini, DNA ligase catalytic activity can generate and/or exacerbate DNA damage through abortive ligation that produces chemically adducted, toxic 5'-adenylated (5'-AMP) DNA lesions....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Monophosphate
Share to Apraxias
Share to Ataxia Telangiectasia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cerebellar Ataxia

Share to Exodeoxyribonucleases

Share to Ribonuclease H

Share to Schizosaccharomyces pombe Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24362567
DOI: 10.1038/nature12824
PMCID: PMC4064939

Genes

APTX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.PMID 24362567Read ↗

Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease.Semantic proximity Read ↗

Short-patch single-strand break repair in ataxia oculomotor apraxia-1.Semantic proximity Read ↗

Aprataxin, a novel protein that protects against genotoxic stressSemantic proximity Read ↗

Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends.Semantic proximity Read ↗

Disease-associated mutations inactivate AMP-lysine hydrolase activity of Aprataxin.Semantic proximity Read ↗

Neurological disorders associated with DNA strand-break processing enzymes.Semantic proximity Read ↗

DNA3'pp5'G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition.Semantic proximity Read ↗

A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage.Semantic proximity Read ↗

Early-onset ataxia with ocular motor apraxia and hypoalbuminemia/ataxia with oculomotor apraxia 1.Semantic proximity Read ↗

Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxinSemantic proximity Read ↗

DNA single-strand break repair is impaired in aprataxin-related ataxia.Semantic proximity Read ↗

The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.