Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic interactions between HNT3/Aprataxin and RAD27/FEN1 suggest parallel pathways for 5' end processing during base excision repair.

DNA repair - 4 Jun 2010

Daley James M, Wilson Thomas E, Ramotar Dindial

Abstract excerpt

Mutations in Aprataxin cause the neurodegenerative syndrome ataxia oculomotor apraxia type 1. Aprataxin catalyzes removal of adenosine monophosphate (AMP) from the 5' end of a DNA strand, which results from an aborted attempt to ligate a strand break containing a damaged end. To gain insight into...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Monophosphate
Share to Alkylation
Share to DNA Breaks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flap Endonucleases

Share to Methyl Methanesulfonate

Share to Rad51 Recombinase

Share to Rad52 DNA Repair and Recombination Protein

Share to Zinc Fingers

Source

Open in PubMed Open full text

Identifiers

PMID: 20399152
DOI: 10.1016/j.dnarep.2010.03.006
PMCID: PMC3319107

Genes

FEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20399152-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic interactions between HNT3/Aprataxin and RAD27/FEN1 suggest parallel pathways for 5' end processing during base excision repair.PMID 20399152Read ↗

Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxinSemantic proximity Read ↗

Aprataxin, a novel protein that protects against genotoxic stressSemantic proximity Read ↗

Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.Semantic proximity Read ↗

Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends.Semantic proximity Read ↗

CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response.Semantic proximity Read ↗

DNA single-strand break repair is impaired in aprataxin-related ataxia.Semantic proximity Read ↗

Early-onset ataxia with ocular motor apraxia and hypoalbuminemia/ataxia with oculomotor apraxia 1.Semantic proximity Read ↗

Major oxidative products of cytosine are substrates for the nucleotide incision repair pathway.Semantic proximity Read ↗

Short-patch single-strand break repair in ataxia oculomotor apraxia-1.Semantic proximity Read ↗

The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability.Semantic proximity Read ↗

Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damageSemantic proximity Read ↗

The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.