Article
Usefulness of peptide nucleic acid (PNA)-clamp smart amplification process version 2 (SmartAmp2) for clinical diagnosis of KRAS codon 12 mutations in lung adenocarcinoma: comparison of PNA-clamp SmartAmp2 and PCR-related methods.
The Journal of molecular diagnostics : JMD - 1 Jan 2010
Araki Takuya, Shimizu Kimihiro, Nakamura Katsunori, Nakamura Tomonori, Mitani Yasumasa, Obayashi Kyoko, Fujita Yukiyoshi, Kakegawa Seiichi, Miyamae Yohei, Kaira Kyoichi, Ishidao Takefumi, Lezhava Alexander, Hayashizaki Yoshihide, Takeyoshi Izumi, Yamamoto Koujirou
Abstract excerpt
KRAS is an oncogene that can be activated by mutations. Patients with non-small cell lung cancer who have KRAS mutations do not respond to tyrosine kinase inhibitors; therefore, accurate detection of KRAS mutations is important for deciding therapeutic strategies. Although sequencing-related tech...
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