Article
Mutation detection of epidermal growth factor receptor and KRAS genes using the smart amplification process version 2 from formalin-fixed, paraffin-embedded lung cancer tissue.
The Journal of molecular diagnostics : JMD - 1 Mar 2010
Miyamae Yohei, Shimizu Kimihiro, Mitani Yasumasa, Araki Takuya, Kawai Yuki, Baba Masaru, Kakegawa Seiichi, Sugano Masayuki, Kaira Kyoichi, Lezhava Alexander, Hayashizaki Yoshihide, Yamamoto Koujirou, Takeyoshi Izumi
Abstract excerpt
Recent evidence indicates that the presence of epidermal growth factor receptor (EGFR) or KRAS mutations in non-small cell lung cancer (NSCLC) can predict the response of the tumor to gefinitib. However, it is difficult to detect these mutations using formalin-fixed, paraffin-embedded (FFPE) tiss...
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