Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brain-Derived Neurotrophic Factor Reduces Amyloidogenic Processing through Control of SORLA Gene Expression

9 Dec 2009

Abstract excerpt

Sorting protein-related receptor with A-type repeats (SORLA) is a major risk factor in cellular processes leading to Alzheimer's disease (AD). It acts as sorting receptor for the amyloid precursor protein (APP) that regulates intracellular trafficking and processing into amyloidogenic-beta peptides (A beta). Overexpression of SORLA in neurons reduces while inactivation of gene expression (as in knock-out mouse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Nerve injury and regeneration
Share to Neurogenesis and neuroplasticity mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20007471
DOI: 10.1523/jneurosci.3960-09.2009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brain-Derived Neurotrophic Factor Reduces Amyloidogenic Processing through Control of SORLA Gene ExpressionPMID 20007471Read ↗

An alternative transcript of the Alzheimer's disease risk gene SORL1 encodes a truncated receptor.Semantic proximity Read ↗

Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease.Semantic proximity Read ↗

A Study of the SORL1 Gene in the Pathogenesis of Late-onset Alzheimer’s Disease by Affecting the Expression of BDNFSemantic proximity Read ↗

Potentially Pathogenic SORL1 Mutations Observed in Autosomal-Dominant Cases of Alzheimer's Disease Do Not Modulate APP Physiopathological Processing.Semantic proximity Read ↗

Lysosomal Sorting of Amyloid-β by the SORLA Receptor Is Impaired by a Familial Alzheimer’s Disease MutationSemantic proximity Read ↗

Familial Alzheimer disease mutation identifies novel role of SORLA in release of neurotrophic exosomesSemantic proximity Read ↗

SORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration.Semantic proximity Read ↗

Sortilin-Related Receptor Expression in Human Neural Stem Cells Derived from Alzheimer's Disease Patients Carrying the APOE Epsilon 4 Allele.Semantic proximity Read ↗

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.Semantic proximity Read ↗

Potentially pathogenic SORL1 mutations observed in autosomal-dominant cases of Alzheimer’s disease do not modulate bAPP physiopathological processingSemantic proximity Read ↗

The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neuronsSemantic proximity Read ↗

SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid depositionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.