Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Temporal control of immediate early gene induction by light.

PloS one - 4 Dec 2009

Schoenenberger Philipp, Gerosa Daniela, Oertner Thomas G

Abstract excerpt

BACKGROUND: The light-gated cation channel channelrhodopsin-2 (ChR2) is a powerful tool for the optical induction of action potentials in neurons. Mutations of the cysteine 128 (C128) residue have been shown to greatly extend the lifetime of the conducting state of ChR2. However, until now, only subthreshold depolarizations have been reported from C128 mutants. METHODS AND FINDINGS: Here we report the induction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Cell Adhesion
Share to Genes, Immediate-Early

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Channel Gating

Share to Organ Specificity

Share to Proto-Oncogene Proteins c-fos

Share to Pyramidal Cells

Share to Rhodopsin

Source

Open in PubMed Open full text

Identifiers

PMID: 19997631
DOI: 10.1371/journal.pone.0008185
PMCID: PMC2780714

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Temporal control of immediate early gene induction by light.PMID 19997631Read ↗

Ultrafast optogenetic control.Semantic proximity Read ↗

Optogenetic long-term manipulation of behavior and animal development.Semantic proximity Read ↗

Modeling study of the light stimulation of a neuron cell with channelrhodopsin-2 mutants.Semantic proximity Read ↗

Computational modeling of channelrhodopsin-2 photocurrent characteristics in relation to neural signaling.Semantic proximity Read ↗

Unraveling ChR2-driven stochastic Ca <sup>2+</sup> dynamics in astrocytes – A call for new interventional paradigmsSemantic proximity Read ↗

Tagging active neurons by soma-targeted Cal-LightSemantic proximity Read ↗

Optogenetic Modeling of Wake-Like Transcriptional Progression in Human SH-SY5Y Neuronal CellsSemantic proximity Read ↗

ChR2 mutants at L132 and T159 with improved operational light sensitivity for vision restoration.Semantic proximity Read ↗

Two-photon imaging induces brain heating and calcium microdomain hyperactivity in cortical astrocytesSemantic proximity Read ↗

Melanopsin Variants as Intrinsic Optogenetic On and Off Switches for Transient versus Sustained Activation of G Protein Pathways.Semantic proximity Read ↗

High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics.Semantic proximity Read ↗

Efficient and sustained optogenetic control of sensory and cardiac systemsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.