Article
Optogenetic long-term manipulation of behavior and animal development.
PloS one - 20 Apr 2011
Schultheis Christian, Liewald Jana Fiona, Bamberg Ernst, Nagel Georg, Gottschalk Alexander
Abstract excerpt
Channelrhodopsin-2 (ChR2) is widely used for rapid photodepolarization of neurons, yet, as it requires high-intensity blue light for activation, it is not suited for long-term in vivo applications, e.g. for manipulations of behavior, or photoactivation of neurons during development. We used "slow" ChR2 variants with mutations in the C128 residue, that exhibit delayed off-kinetics and increased light sensitivity...
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