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Article

Online tool to guide decisions for BRCA1/2 mutation carriers.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Feb 2012

Kurian Allison W, Munoz Diego F, Rust Peter, Schackmann Elizabeth A, Smith Michael, Clarke Lauren, Mills Meredith A, Plevritis Sylvia K

Abstract excerpt

PURPOSE: Women with BRCA1 or BRCA2 (BRCA1/2) mutations must choose between prophylactic surgeries and screening to manage their high risks of breast and ovarian cancer, comparing options in terms of cancer incidence, survival, and quality of life. A clinical decision tool could guide these complex choices. METHODS: We built a Monte Carlo model for BRCA1/2 mutation carriers, simulating breast screening with annual...

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Source

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Identifiers

PMID: 22231042
DOI: 10.1200/JCO.2011.38.6060
PMCID: PMC3295552

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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