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Article

Effect of prevention strategies on survival and quality-adjusted survival of women with BRCA1/2 mutations: an updated decision analysis.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 May 2002

Grann Victor R, Jacobson Judith S, Thomason Dustin, Hershman Dawn, Heitjan Daniel F, Neugut Alfred I

Abstract excerpt

PURPOSE: This study updates findings regarding the effects of prophylactic surgery, chemoprevention, and surveillance on the survival and quality-adjusted survival of women who test positive for BRCA1/2 mutations. MATERIALS AND METHODS: Markov modeling of outcomes was performed in a simulated cohort of 30-year-old women who tested positive for BRCA1/2 mutations. The model incorporated breast and ovarian cancer...

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Source

Identifiers

PMID: 12011131
DOI: 10.1200/JCO.2002.10.101

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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