Article
Ovarian stimulation for IVF and risk of primary breast cancer in BRCA1/2 mutation carriers.
British journal of cancer - 1 May 2018
Derks-Smeets Inge A P, Schrijver Lieske H, de Die-Smulders Christine E M, Tjan-Heijnen Vivianne C G, van Golde Ron J T, Smits Luc J, Caanen Beppy, van Asperen Christi J, Ausems Margreet, Collée Margriet, van Engelen Klaartje, Kets C Marleen, van der Kolk Lizet, Oosterwijk Jan C, van Os Theo A M, Rookus Matti A, van Leeuwen Flora E, Gómez García Encarna B
Abstract excerpt
BACKGROUND: The effect of in vitro fertilisation (IVF) on breast cancer risk for BRCA1/2 mutation carriers is rarely examined. As carriers may increasingly undergo IVF as part of preimplantation genetic diagnosis (PGD), we examined the impact of ovarian stimulation for IVF on breast cancer risk in BRCA1/2 mutation carriers. METHODS: The study population consisted of 1550 BRCA1 and 964 BRCA2 mutation carriers,...
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