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Article

Immunoprotective Sertoli cells: making allogeneic and xenogeneic transplantation feasible

8 Dec 2009

Abstract excerpt

The testis as an immune-privileged site allows long-term survival of allogeneic and xenogeneic transplants. Testicular Sertoli cells (SCs) play a major role in this immunoprotection and have been used to create an ectopic immune-privileged environment that prolongs survival of co-transplanted allogeneic and xenogeneic cells, including pancreatic islets and neurons. Extended survival of such grafts testifies to...

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PMID: 19995832
DOI: 10.1530/rep-09-0384

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