Article
Distamycin inhibits the binding of a nuclear factor to the -278/-256 upstream sequence of the human HLA-DR alpha gene.
Biochemical pharmacology - 15 Feb 1991
Gambari R, Barbieri R, Nastruzzi C, Chiorboli V, Feriotto G, Natali P G, Giacomini P, Arcamone F
Abstract excerpt
In this study we analyse the effects of the anti-tumor compound distamycin on the binding of nuclear factor(s) to a synthetic oligonucleotide (GTATA/IFN-gamma) mimicking a putative regulatory region of the human HLA-DR alpha gene. This region contains the sequence (GTATA), that is required for nuclear protein binding and is likely to interact with distamycin. The present results, by showing that distamycin...
Topics
- Antineoplastic Agents
- Base Sequence
- Distamycins
- HLA-DR Antigens
- Humans
- Mutation
- Nuclear Proteins
- Oligonucleotides
- Promoter Regions, Genetic