Article
Differential genomic susceptibility in malignancy correlates with changes in ATATAT DNA-binding proteins.
Biochemical and biophysical research communications - 15 Aug 1991
Rieber M S, Rieber M
Abstract excerpt
Accesibility to DNA in the nucleus is important for the regulation of gene expression and for the effect of DNA-modifying drugs. We have now studied differential genome susceptibility in normal melanocytes and the corresponding malignant melanoma. DNA hypersensitivity assays revealed a markedly l...
Topics
- Animals
- Base Sequence
- Carcinogens
- Cell Transformation, Neoplastic
- Cells, Cultured
- Cholera Toxin
- DNA-Binding Proteins
- Embryo, Mammalian
- Ethers, Cyclic
- Genetic Predisposition to Disease
- Melanocytes
- Melanoma, Experimental
- Mice
- Mice, Inbred C57BL
- Nuclear Proteins
- Okadaic Acid
- Substrate Specificity
- Tetradecanoylphorbol Acetate
