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Article

Developmental abnormalities and cancer predisposition in neurofibromatosis type 1.

Current molecular medicine - 1 Jun 2009

Larizza Lidia, Gervasini Cristina, Natacci Federica, Riva Paola

Abstract excerpt

Neurofibromatosis type 1 (NF1) is a developmental and cancer predisposing syndrome resulting from haploinsufficiency or alteration in neurofibromin, a multifunctional protein that acts in various signaling pathways affecting morphogenetic processes and cell proliferation. Neurofibromin deficiency deregulates Ras/Raf/MEK/ERK and Ras/PI3K/AKT/PKB/mTOR signaling networks and intersected pathways including the...

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Source

Identifiers

PMID: 19601812
DOI: 10.2174/156652409788488801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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