Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multi-scale modeling of excitation-contraction coupling in the normal and failing heart.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference - 1 Jan 2009

Kerckhoffs Roy C P, Campbell Stuart G, Flaim Sarah N, Howard Elliot J, Sierra-Aguado Jazmin, Mulligan L J, McCulloch Andrew D

Abstract excerpt

Here we describe new computational models of cardiac electromechanics starting from the cellular scale and building to the tissue, organ and system scales. We summarize application to human genetic diseases (LQT1 and LQT3) and to modeling of congestive heart failure.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electrophysiology
Share to Equipment Design

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Conduction System

Share to Heart Failure

Share to Long QT Syndrome

Share to Models, Cardiovascular

Share to Muscle Cells

Share to Myocardial Contraction

Source

Open in PubMed Open full text

Identifiers

PMID: 19963818
DOI: 10.1109/IEMBS.2009.5332708
PMCID: PMC2896048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multi-scale modeling of excitation-contraction coupling in the normal and failing heart.PMID 19963818Read ↗

T-World: A highly general computational model of a human ventricular myocyteSemantic proximity Read ↗

Interpreting genetic effects through models of cardiac electromechanics.Semantic proximity Read ↗

Multi-scale computational models of familial hypertrophic cardiomyopathy: genotype to phenotype.Semantic proximity Read ↗

Integrative models of the heart: achievements and limitationsSemantic proximity Read ↗

Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2.Semantic proximity Read ↗

An In Silico Cardiomyocyte Reveals the Impact of Changes in CaMKII Signalling on Cardiomyocyte Contraction Kinetics in Hypertrophic Cardiomyopathy.Semantic proximity Read ↗

Arrhythmogenic influence of mutations in a myocyte-based computational model of the pulmonary vein sleeve.Semantic proximity Read ↗

An <i>in silico</i> Cardiomyocyte Reveals the Impact of Changes in CAMKII Signalling on Cardiomyocyte Contraction Kinetics in Hypertrophic CardiomyopathySemantic proximity Read ↗

Modeling the Heart--from Genes to Cells to the Whole OrganSemantic proximity Read ↗

Computational biology in the study of cardiac ion channels and cell electrophysiology.Semantic proximity Read ↗

Human atrial fibrillation and genetic defects in transient outward currents: mechanistic insights from multi-scale computational models.Semantic proximity Read ↗

From genome to physiome: integrative models of cardiac excitation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.