Article
Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator-activated receptor-alpha gene expression signature in SAMP1 mice.
Molecular nutrition & food research - 1 Jun 2010
Schmelzer Constance, Kubo Hiroshi, Mori Masayuki, Sawashita Jinko, Kitano Mitsuaki, Hosoe Kazunori, Boomgaarden Inka, Döring Frank, Higuchi Keiichi
Abstract excerpt
Our present study reveals significant decelerating effects on senescence processes in middle-aged SAMP1 mice supplemented for 6 or 14 months with the reduced form (Q(10)H(2), 500 mg/kg BW/day) of coenzyme Q(10) (CoQ(10)). To unravel molecular mechanisms of these CoQ(10) effects, a genome-wide tra...
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