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Helicobacter pylori CagA upregulation of CIP2A is dependent on the Src and MEK/ERK pathways

4 Dec 2009

Abstract excerpt

Helicobacter pylori is classified as a class I carcinogenic factor and its persistent colonization in the stomach induces gastric cancer. Cancerous Inhibitor of PP2A (CIP2A) is a newly identified oncoprotein overexpressed in gastric cancer. Serving as a key oncoprotein, CIP2A also participates in regulation of senescence and proliferation of gastric cells. The combination of aberrant CIP2A expression inducing...

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PMID: 19959630
DOI: 10.1099/jmm.0.014704-0

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