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CIP2A Is Overexpressed in Gastric Cancer and Its Depletion Leads to Impaired Clonogenicity, Senescence, or Differentiation of Tumor Cells

15 Jun 2008

Abstract excerpt

PURPOSE: Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncogenic factor stabilizing c-MYC protein and driving cellular transformation. We determine whether CIP2A expression can serve as marker for gastric cancer and investigate the mechanism underlying CIP2A-mediated transformation and cell proliferation. EXPERIMENTAL DESIGN: Normal and malignant gastric tissues derived from 37 patients with gastric...

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PMID: 18559589
DOI: 10.1158/1078-0432.ccr-07-4137

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CIP2A Is Overexpressed in Gastric Cancer and Its Depletion Leads to Impaired Clonogenicity, Senescence, or Differentiation of Tumor CellsPMID 18559589Read ↗

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