Article
Arginine 15 stabilizes an S(N)Ar reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1.
Biophysical chemistry - 1 Feb 2010
Gildenhuys Samantha, Dobreva Marina, Kinsley Nichole, Sayed Yasien, Burke Jonathan, Pelly Stephen, Gordon Graeme P, Sayed Muhammed, Sewell Trevor, Dirr Heini W
Abstract excerpt
Arg15, conserved in class Alpha GSTs (glutathione transferases), is located at the interface between the G- and H-sites of the active site where its cationic guanidinium group might play a role in catalysis and ligand binding. Arg15 in human GSTA1-1 was replaced with a leucine and crystallographic, spectroscopic, thermodynamic and molecular docking methods were used to investigate the contribution made by Arg15...
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