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Article

Tertiary interactions stabilise the C-terminal region of human glutathione transferase A1-1: a crystallographic and calorimetric study.

Journal of molecular biology - 17 Jun 2005

Kuhnert Diane C, Sayed Yasien, Mosebi Salerwe, Sayed Muhammed, Sewell Trevor, Dirr Heini W

Abstract excerpt

The C-terminal region in class Alpha glutathione transferase A1-1 (GSTA1-1), which forms an amphipathic alpha-helix (helix 9), is known to contribute to the catalytic and non-substrate ligand-binding functions of the enzyme. The region in the apo protein is proposed to be disordered which, upon ligand binding at the active-site, becomes structured and localised. Because Ile219 plays a pivotal role in the...

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Source

Identifiers

PMID: 15893769
DOI: 10.1016/j.jmb.2005.04.025

Genes

GSTA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tertiary interactions stabilise the C-terminal region of human glutathione transferase A1-1: a crystallographic and calorimetric study.PMID 15893769Read ↗

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