Article
Role of Ser11 in the stabilization of the structure of Ochrobactrum anthropi glutathione transferase.
The Biochemical journal - 15 Apr 2007
Federici Luca, Masulli Michele, Bonivento Daniele, Di Matteo Adele, Gianni Stefano, Favaloro Bartolo, Di Ilio Carmine, Allocati Nerino
Abstract excerpt
GSTs (glutathione transferases) are a multifunctional group of enzymes, widely distributed and involved in cellular detoxification processes. In the xenobiotic-degrading bacterium Ochrobactrum anthropi, GST is overexpressed in the presence of toxic concentrations of aromatic compounds such as 4-c...
Topics
- Circular Dichroism
- Crystallography, X-Ray
- Dimerization
- Enzyme Stability
- Glutathione Transferase
- Kinetics
- Models, Molecular
- Mutation
- Ochrobactrum anthropi
- Protein Folding
- Protein Structure, Quaternary
- Serine
- Structural Homology, Protein
- Substrate Specificity