Article
Glutathione transferase A1-1: catalytic importance of arginine 15.
The journal of physical chemistry. B - 4 Feb 2010
Dourado Daniel F A R, Fernandes Pedro Alexandrino, Mannervik Bengt, Ramos Maria João
Abstract excerpt
Glutathione transferases (GSTs) are fundamental enzymes of the cell detoxification system. They catalyze the nucleophilic attack of glutathione (GSH) on electrophilic substrates to produce less toxic compounds. The resulting substrate can then be recognized by ATP-dependent transmembrane pumps and consequently expelled from the cell. Despite all the existing studies on GSTs, many aspects of the catalytic events...
Topics
- Arginine
- Biocatalysis
- Biological Transport
- Catalytic Domain
- Glutathione Transferase
- Humans
- Mutation
- Protons