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Article

Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3

16 Feb 2008

Abstract excerpt

Hypoxia (lack of oxygen) is a physiological stress often associated with solid tumors. Hypoxia correlates with poor prognosis since hypoxic regions within tumors are considered apoptosisresistant. Autophagy (cellular "self digestion") has been associated with hypoxia during cardiac ischemia and metabolic stress as a survival mechanism. However, although autophagy is best characterized as a survival response, it...

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PMID: 18059169
DOI: 10.4161/auto.5278

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