Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death.

Human molecular genetics - 1 Jan 2001

Putaala H, Soininen R, Kilpeläinen P, Wartiovaara J, Tryggvason K

Abstract excerpt

A mouse model for congenital nephrotic syndrome (NPHS1) was generated by inactivating the nephrin gene (Nphs1) in embryonic stem cells by homologous recombination. The targeting construct contained the Escherichia coli lacZ gene as a reporter for the Nphs1 promoter. Mice homozygous for inactivate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to beta-Galactosidase
Share to Edema

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Targeting

Share to Microscopy, Electron

Share to Organ Size

Share to Pancreas

Share to Proteinuria

Source

Identifiers

PMID: 11136707
DOI: 10.1093/hmg/10.1.1

Genes

NPHS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11136707-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death.PMID 11136707Read ↗

Two Gene Fragments that Direct Podocyte-Specific Expression in Transgenic MiceSemantic proximity Read ↗

An inducible mouse model of podocin-mutation-related nephrotic syndrome.Semantic proximity Read ↗

Glomerular-Specific Gene Excision In VivoSemantic proximity Read ↗

Tissue expression of nephrin in human and pig.Semantic proximity Read ↗

Quantitative phenotyping of Nphs1 knockout mice as a prerequisite for gene replacement studies.Semantic proximity Read ↗

Inducible nephrin transgene expression in podocytes rescues nephrin-deficient mice from perinatal death.Semantic proximity Read ↗

NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome.Semantic proximity Read ↗

Nephrin TRAP mice lack slit diaphragms and show fibrotic glomeruli and cystic tubular lesions.Semantic proximity Read ↗

Quantifiable and reproducible phenotypic assessment of a constitutive knockout mouse model for congenital nephrotic syndrome of the Finnish type.Semantic proximity Read ↗

Proteinuria and Perinatal Lethality in Mice Lacking NEPH1, a Novel Protein with Homology to NEPHRINSemantic proximity Read ↗

Glomerular sclerosis in kidneys with congenital nephrotic syndrome (NPHS1).Semantic proximity Read ↗

WT1 Activates a Glomerular-Specific Enhancer Identified from the Human Nephrin GeneSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.