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Article

Identification of a functionally important loop in Salmonella typhimurium ArnT.

Biochemistry - 12 Jan 2010

Impellitteri Nicholas A, Merten Jacqueline A, Bretscher Lynn E, Klug Candice S

Abstract excerpt

ArnT confers resistance to the antibiotic polymyxin in Salmonella typhimurium and Escherichia coli through the modification of lipid A, a major component of the outer surface of gram-negative bacteria. ArnT transfers a neutral aminoarabinose moiety onto the negative phosphate groups of lipid A, reducing the surface charge of the bacteria and preventing cationic peptides such as polymyxin from electrostatically...

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Identifiers

PMID: 19947657
DOI: 10.1021/bi901572f
PMCID: PMC2805049

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