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Article

Contribution of germline mutations to PARK2 gene inactivation in lung adenocarcinoma.

Genes, chromosomes & cancer - 1 May 2012

Iwakawa Reika, Okayama Hirokazu, Kohno Takashi, Sato-Otsubo Aiko, Ogawa Seishi, Yokota Jun

Abstract excerpt

Homozygous germline mutations of the PARK2 gene are responsible for the development of early-onset Parkinson's disease (PD). Homozygous PARK2 mutations have been also detected in lung adenocarcinoma (LADC). However, since heterozygous PARK2 germline mutations are present in a subset of non-PD individuals, the timing for the occurrence of two-hit PARK2 mutations in LADC progression is unclear. Therefore, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22302706
DOI: 10.1002/gcc.21933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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